Hey Smooth,
Not sure about your question. Negative health consequences are definitely dose/duration dependent, and age related. Just listen to your body. If your mouth develops soarness/sensitivities you relate to smoking you may want to take a break until it clears up. If your breathing is not as effortless as before smoking, you may want to take a break until you are comfortable with it again. Negative effects from nicotine are more subtle and harder to perceive. Although you can feel differences in heart rhythms, blood flow through touch sensitivity and body temperatures.
It's also highly dependent on the individual.
If you are living a clean, healthy life with the exception of cigars, you can still be quite the specimen.
If you have many unhealthy habits in addition to cigars, the negative effects will surely be amplified.
Generally, long-term effects are reached after long-term use.
Not sure if this is helpful but felt obligated to give some sort of response.
Tony