I'm currently playing in two bands one is a four piece and the other is a two piece, we setup similarly every gig it varies based on the stage size and monitor locations.
With the four piece (drums, guitar/vocals, bass/vocals, and a lead singer) I setup fairly far back but in the center of the stage, guitar to my left, bass to my right, lead singer wherever the fuck he wants to go! It's the perfect setup as far as space and sound goes but it's straight up terrible if the drummer wants to be in ANY of the photos of the performance!
With the two piece (drums, guitar/vocals) I setup pretty close to the front of the stage with the primary guitar amp to my immediate left, he uses two amps and an a/b/y switch so even if the stage sound is terrible I can still hear guitar.