Your vaccination against paragraphs might be wearing off. You've put TWO in one comment!So did it leave you with any permanent issues like exercise asthma when you bike or anything or you back to full capacity? That's interesting the load theory-one concern I have is are we limiting our exposure to other viruses that don't cause disease but activate our immunity to give us cross-protection. I was just reading the paper isolating the T cells that recognize SARS-COV-2 in asymptomatic people and their evidence likely cross-protection (it was CD 4 helper memory cells and no antibodies to spike) from a benign coronavirus. Lots of studies in kids how being too clean is actually unhealthy-activating our immunity increases our health apparently.
There is non-specific effects of developing natural immunity and vaccine immunity that are beneficial -"The central paradigm of vaccination is to generate resistance to infection by a specific pathogen when the vacinee is re-exposed to that pathogen. This paradigm is based on two fundamental characteristics of the adaptive immune system, specificity and memory. These characteristics come from the clonal specificity of T and B cells and the long-term survival of previously-encountered memory cells which can rapidly and specifically expand upon re-exposure to the same specific antigen. However, there is an increasing awareness of the concept, as well as experimental documentation of, heterologous immunity and cross-reactivity of adaptive immune lymphocytes in protection from infection. This awareness is supported by a number of human epidemiological studies in vaccine recipients and/or individuals naturally-resistant to certain infections, as well as studies in mouse models of infections, and indeed theoretical considerations regarding the disproportional repertoire of available T and B cell clonotypes compared to antigenic epitopes found on pathogens. Heterologous immunity can broaden the protective outcomes of vaccinations, and natural resistance to infections. Besides exogenous microbes/pathogens and/or vaccines, endogenous microbiota can also impact the outcomes of an infection and/or vaccination through heterologous immunity. Moreover, utilization of viral and/or bacterial vaccine vectors, capable of inducing heterologous immunity may also influence the natural course of many infections/diseases. This review article will briefly discuss these implications and redress the central dogma of specificity in the immune system." So we can be too isolated with a goal of reducing flu or coronaviruses with interventions and have collateral damage of weakening our population immunity-like kids had no immunity to H1N1 but a lot of adults had partial immunity-likely cross-reactivity or years of vaccinations to other flu strains.