I am glad you brought up Twenty One Pilots.A great band that plays to backing tracks and manipulates them on the fly is Twenty-One Pilots. First time I saw these guys (a duo), and how they performed, I had no clue how they did it (played along so seamlessly to the backing tracks). Then it dawned on me that this was new-school and showed legitimate talent.
Recently I started to think that use of backing tracks was starting to reduce many artists' gigs to glorified karaoke shows.
However this week I saw Twenty One Pilots and they have a fantastic live show.
They have made me feel a lot better about the future of live music!