I'm constantly trying to tweak my 14,18,26,15 setup to make it more ergonomic. I love the depth and breadth of the huge sizes, but sometimes I find them less than optimal positioning-wise. Not so much with the 15" snare, but the combination of the 14 and 18 toms around a 26 bass drum doesn't always make for a tight setup.
I own a Vector pedal though, so that makes things WAY better than trying to setup around a pedal that can't be offset or tilted in relation to the bass drum. I'm left handed and purposely bought a righty pedal so I could offset my position over to the right in relation to the bass drum, which makes the position of the 14" tom way lower, and also so I could cant the pedal to the left so I can set up the bass drum straight instead of canted to the left. That allows me to keep an already large 18" floor tom more in front of me instead of over to the side/almost a bit behind me. Lately however, I've actually started setting up the bass drum so it's actually chanted over to the right a bit. The pedal facilitates this, and it looks a bit weird, but it allows me to get my floor tom in front and over to the right even more, which tightens up my tom setup considerably.