I use an x32 as a live desk at work (I really am a lucky bugger, Audient ASP 4816 in the studio, x32 upstairs) and I don't think it has room calibration.
I will say that it's just about the easiest and most intuitive digital desk I've ever used. We run it with the S16 snake, which is just fantastic and gives you your channels on Cat5 - great if you're at the back of an auditorium and the band is at the front like with us.
Everything is clearly laid out, the menus are easy to navigate, the EQ is decent, the compressor is decent, the reverbs are decent and the preamps are decent. The motorised faders are great and if you set scenes properly, incredibly useful. One of the most useful things I find with the x32 is being able to re-assign channel inputs. You might have a mic plugged into preamp 1 but want to control it from channel 26 (for instance) and you can quickly and painlessly re-assign it. The coloured and labelled channel strips are great too. It's just a fantastic desk.
If you want it as a studio interface and live desk, get the interface card (it's a bit extra) and use it that way. You don't lose any live capability. You can just plug in a USB stick (up to 8GB, I found out the hard way) and select a buss to record a stereo file from. I usually just use the master. Useful for capturing live shows but you don't have any mixdown capability afterwards - just a stereo track.
I will honestly say that it's the best live desk I've ever used for ease of use and quality of result. I usually hate digital desks for live use but the x32 is very much the exception. And it's not that expensive, either.