Re: Amarillo, TX
The closest I've been is Lubbock, which is about 2 hours south if I remember correctly. I'm a Buddy Holly fan so it was great to see his hometown and memorial.
That whole area is the middle of nowhere. (Side-note: I saw my first-ever tumbleweed there. No kidding, it went through a downtown intersection right along with the cars. Weird...)
And as Mike said, it's REALLY hot; definitely pack the sunscreen. That place is hotter than the sun's a$$.