Zoom definitely hadn't upgraded their drivers to use their R16 and R24 as interfaces yet either.
Small update on this. The issue appears to be on the Apple side. The users that are experiencing the KPanic and noise issue appear to be those using USB3. The issue appears to be resolved in the current beta OS X 10.10.3 (14D113c) which should be released in a few weeks.
The old issues are still present. Desync on a long-held midi note, eventual desync if you leave the R16 active and turned on for long periods. I am under the impression that these are Zoom issues.
Bo, when you plug your R16 in, do you see it under system-preferences/sound?